소장자료

NMR-based metabolomics: methods and protocols [electronic resource]

  • Gowda, G. A. Nagana , Raftery, Daniel
  • Humana Press
  • 2019
NMR-based metabolomics: methods and protocols [electronic resource]

초록

This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

목차

Historical and Methodological Overview
Overview of NMR Spectroscopy-Based Metabolomics: Opportunities and Challenges / G. A. Nagana Gowda, Daniel Raftery

Metabolite Analysis Methods
Analysis of Plasma, Serum, and Whole Blood Metabolites Using 1H NMR Spectroscopy / G. A. Nagana Gowda, Daniel Raftery
Lipid Profiling Using 1H NMR Spectroscopy / Miriam Gil, Sara Samino, Rubén Barrilero, Xavier Correig
High-Resolution Magic Angle Spinning (HRMAS) NMR Methods in Metabolomics / Marlon Tilgner, Tim S. Vater, Piet Habbel, Leo L. Cheng
Practical Guidelines for 13C-Based NMR Metabolomics / Arthur S. Edison, Adrien Le Guennec, Frank Delaglio, Ēriks Kupče
Analysis of Coenzymes and Antioxidants in Tissue and Blood Using 1D 1H NMR Spectroscopy / G. A. Nagana Gowda, Daniel Raftery

Unknown Resonance Identification
UHPLC-QTOF-MS/MS-SPE-NMR: A Solution to the Metabolomics Grand Challenge of Higher-Throughput, Confident Metabolite Identifications / Anil Bhatia, Saurav J. Sarma, Zhentian Lei, Lloyd W. Sumner
Fast NMR Methods for Identification of Resonances and Metabolic Pathways / Abhinav Dubey, Shivanand M. Pudakalakatti, Hanudatta S. Atreya

Stable Isotope-Resolved NMR
Stable Isotope-Resolved Metabolomics by NMR / Penghui Lin, Andrew N. Lane, Teresa W.-M. Fan
Tracking Metabolic Rewiring of Cancer Metabolism in Humans Using Isotope-Resolved NMR / Kumar Pichumani

Biomarker Discovery
NMR-Based Metabolomics in Cardiac Research / Julian L. Griffin, Cecilia Castro
Breast Cancer Metabolomics Using NMR / Uma Sharma, Naranamangalam R. Jagannathan
NMR-Based Urinary Metabolomics Applications / Tedros Bezabeh, Ana Capati, Omkar B. Ijare
NMR-Based Metabolomics in Gallbladder Cancer Research / Renuka Ranjan, Neeraj Sinha
Biomarker Discovery Using NMR-Based Metabolomics of Tissue / Maria T. Grinde, Guro F. Giskeødegård, Trygve Andreassen, May-Britt Tessem, Tone F. Bathen, Siver A. Moestue

Drug Discovery
NMR Metabolomics Protocols for Drug Discovery / Fatema Bhinderwala, Robert Powers

Environmental Studies
Practical Aspects of the Analysis of Low- and High-Field NMR Data from Environmental Samples / Jun Kikuchi

Food, Nutrition, and Plants
NMR-Based Metabolomics of Food / Ulrik K. Sundekilde, Nina Eggers, Hanne Christine Bertram
Plant Metabolomics Using NMR Spectroscopy / Denise Medeiros Selegato, Alan Cesar Pilon, Fausto Carnevale Neto

Ultrafast and Ultrahigh-Resolution Methods
Fast Quantitative 2D NMR for Untargeted and Targeted Metabolomics / Estelle Martineau, Patrick Giraudeau
Targeted Metabolomics with Quantitative Dissolution Dynamic Nuclear Polarization / Mathilde H. Lerche, Magnus Karlsson, Jan H. Ardenkjær-Larsen, Pernille R. Jensen
Metabolic Profiling Using In Vivo High Field Flow NMR / Maryam Tabatabaei Anaraki, Daniel Lane, Monica Bastawrous, Amy Jenne, André J. Simpson

Automation, Databases and Software Tools
Tools for Enhanced NMR-Based Metabolomics Analysis / John L. Markley, Hesam Dashti, Jonathan R. Wedell, William M. Westler, Hamid R. Eghbalnia
Automated Tools for the Analysis of 1D-NMR and 2D-NMR Spectra / Matthias Lipfert, Manoj Kumar Rout, Mark Berjanskii, David S. Wishart

Data Processing and Statistical Methods
Processing and Analysis of Untargeted Multicohort NMR Data / Timothy M. D. Ebbels, Ibrahim Karaman, Gonçalo Graça
Advanced Statistical Methods for NMR-Based Metabolomics / Dabao Zhang, Min Zhang