소장자료

T2-shortening effect of gadolinium with optimal condition to increase CNR for the evaluation of biliary system : phantom study

  • 이미정
  • Graduate School, Yonsei University
  • 2010
T2-shortening effect of gadolinium with optimal condition to increase CNR for the evaluation of biliary system : phantom study
  • 자료유형
    학위논문
  • 서명/저자사항
    T2-shortening effect of gadolinium with optimal condition to increase CNR for the evaluation of biliary system :phantom study=가돌리늄 조영제의 T2 단축 효과를 이용하여 담도 평가에서 대조잡음비를 높이기 위한 최적의 조건 모색 : 팬텀 연구/Mi-jung Lee.
  • 발행사항
    Seoul : Graduate School, Yonsei University, 2010.
  • 개인저자
    이미정
  • 형태사항
    24 p. : ill. ; 26 cm.
  • 일반주기
    지도교수: Myung-Joon Kim
  • 학위논문주기
    학위논문(박사) -Graduate School, Yonsei University :Dept. of Medicine,2010.8
  • 비통주제명
    자기공명영상 -, 가돌리늄 -, 담도계 -, 팬텀
  • 언어
    영어

소장사항

소장정보
번호 소장처 청구기호 도서상태 반납예정일 신청/예약
1 연세의학도서관/학위논문서가/교내공개(PDF) T 대출불가(별치) -

초록

[한글]
[영문]PURPOSE: In evaluating neonatal cholestasis, depiction of common bile duct is important to exclude biliary atresia in which early operation is needed. During MRCP, T2-shortening effect of gadolinium can increase contrast-to-noise ratio (CNR) of bile duct and enhance the depiction of it. The purpose of this study is to confirm the T2-shortening effect of gadolinium, to evaluate the effect of different gadolinium chelate with different gadolinium concentrations and different magnetic field strength to suggest the optimal combination of these conditions, and to find the maximum CNR for the evaluation of biliary system using a phantom study.MATERIALS AND METHODS: MR imaging of T2-weighted single-shot fast spin echo sequence and T2 relaxometry were performed with a sponge phantom and a syringe tube. Two contrasts (Gd-DTPA and Gd-EOB-DTPA) with different gadolinium concentrations were evaluated in 1.5T and 3T. Signal intensities, CNRs, and T2 relaxation time were analyzed.RESULTS: Signal intensities decreased significantly as gadolinium concentrations increased (p<0.001) with both contrasts. And these were higher on 3T (p<0.001). CNRs were higher on 1.5T (p<0.001) and showed no significant change with different gadolinium concentrations. T2 relaxation time also showed a negative correlation with gadolinium concentrations (p<0.001) and decreased more with Gd-EOB-DTPA (than Gd-DTPA; p<0.001) on 3T (than 1.5T; p<0.001).CONCLUSION: There is a T2-shortening effect of gadolinium which shows a negative correlation with gadolinium concentration in both signal intensities and T2 relaxation time. Higher CNR could be obtained with Gd-DTPA on 1.5T.

목차

[한글]
[영문]Abstract
I. Introduction
II. Materials and methods
1. Preliminary study
2. Phantom study
3. MR imaging
4. Image analysis
5. Statistical analysis
III. Results
1. Signal intensity
2. Contrast-to-noise raios (CNRs)
3. T2 relaxation time
IV. Discussion
V. Conclusion
References
Abstract (In Korean)