소장자료

Pharmacotherapeutics of the Thyroid Gland [electronic resource]

  • Weetman, A. P. editor. , Grossman, A. editor.
  • 1997
Pharmacotherapeutics of the Thyroid Gland [electronic resource]
  • 자료유형
    단행본
  • 서명/저자사항
    Pharmacotherapeutics of the Thyroid Gland[electronic resource] / edited by A. P. Weetman, A. Grossman.
  • 대등서명
    With contributions by numerous experts.
  • 개인저자
    Weetman, A. P., editor., Grossman, A., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    XVIII, 370 p. : online resource.
  • 총서명
    Handbook of Experimental Pharmacology,0171-2004 ; 128
  • 내용주기
    1 Introduction: Clinical Aspects of Thyroid Treatment -- A. Introduction -- B. Choices of Treatment for the Hyperthyroidism of Graves??Disease -- C. Subclinical Hyperthyroidism -- D. Correct Dose of Thyroxine in Primary Hypothyroidism -- E. Subclinical Hypothyroidism: Treatment or Not? -- References -- 2 Control of TRH and TSH Secretion -- A. Introduction -- B. Negative Feedback Action of Thyroid Hormones -- C. Structure and Actions of TRH -- D. Structure and Actions of Somatostatin -- E. Actions of Neurotransmitters -- F. Actions of Cytokines and Inflammatory Mediators -- G. Physiological and Secondary TSH Changes -- References -- 3 The TSH Receptor -- A. Introduction -- B. TSH Receptor Cloning -- C. Structure of the TSHR in the Human Thyroid Gland -- D. Structure of the TSHR in Transfected Cells -- E. Controversies on Receptor Structure -- F. Expression of the TSH Receptor in the Baculovirus System -- G. Shedding of TSH Receptor Ectodomain in Thyroid and Transfected Cells -- H. Cellular Expression of the TSH Receptor -- I. Intracellular Trafficking of the Receptor -- J. Structure-Function Relationships -- K. Gene Structure and Regulation -- L. The TSH Receptor and Pathology -- M. Conclusions -- References -- 4 Thyroid Hormone Synthesis, Plasma Membrane Transport and Metabolism -- A. Thyroid Hormone Synthesis -- B. Thyroid Hormone Plasma Membrane Transport -- C. Thyroid Hormone Metabolism -- D. Deiodination -- E. Characterization of Iodothyronine Deiodinases -- F. Sulphation -- G. Glucuronidation -- References -- 5 Thyroid Hormone Transport -- A. Introduction -- B. Serum Bingding in Humans -- C. Binding Kinetics -- D. Free Hormone Measurement -- E. Interactions with Competitors -- References -- 6 Molecular Biology of Thyroid Hormone Action -- A. Introduction -- B. Extranuclear Mechanisms of Thyroid Hormone Action -- C. Identification of High-Affinity Nuclear-Binding Sites for Thyroid Hormones -- D. Cloning of cDNAs Encoding Nuclear Receptors for T3 -- E. Recognition of Two Genes Encoding Two Major Classes of TR -- F. Thyroid Hormone Response Elements -- G. Structural Characteristics of TRs and Identification of Functional Domains -- H. Role of the TR Splice Variant TR?2 -- References -- 7 Iodine: Metabolism and Pharmacology -- A. Introduction -- B. Iodide Transport and Organification -- C. Thyroid Autoregulation -- References -- 8 Antithyroid Drugs: Their Mechanism of Action and Clinical Use -- A. Introduction -- B. Hyperthyroidism -- C. Pharmacokinetics -- D. Mechanism of Action -- E. Clinical Use -- F. Conclusions -- References -- 9 Effect of Lithium on the Thyroid Gland -- A. Introduction -- B. Effect on Thyroid Physiology -- C. Effect on the Hypothalamic-Pituitary Axis -- D. Lithium and Cell Function -- E Immunological Effects on Thyroid Function -- F. Effect on Thyroid Hormone Action -- G. Clinical Effects on the Thyroid -- H. Clinical Use in Thyroid Disease -- References -- 10 Amiodarone and the Thyroid -- A. Pharmacology of Amiodarone -- B. Effects of Amiodarone on Thyroid Hormone Secretion and Metabolism -- C. Amiodarone-Induced Thyrotoxicosis and Amiodarone-Induced Hypothyroidism -- D. Amiodarone as a Thyroid Hormone Antagonist -- References -- 11 Effects of Other Pharmacological Agents on Thyroid Function -- A. Introduction -- B. Effects of Various Drugs on Thyroidal Hormonogenesis -- C. Effects of Drugs on Thyroid Hormone Metabolism -- D. Drug Effects on Cellular and Intestinal Uptake of Thyroid Hormone -- References -- 12 Effects of Environmental Agents on Thyroid Function -- A. Introduction -- B. Chemical Categories, Sources, Pharmacokinetics, and Mechanism of Action -- References -- 13 Thyroid Hormone Antagonism -- A. Introduction -- B Inhibition of Uptake -- C. Cytoplasmic Binding -- D. Antagonism at the Receptor Level -- References -- 14 Immunomodulatory Agents in Autoimmune Thyroid Disease -- A. Introduction -- B. Hormones and Autoimmune Thyroid Disease -- C. Toxins and Autoimmune Thyroid Disease -- D. Trace Elements and Autoimmune Thyroiditis -- E. Drugs and Autoimmune Thyroid Disease -- F. Cytokines and Autoimmune Thyroid Disease -- G. Immunomodulatory Agents in TAO -- References.
  • 일반주제명
    Medicine.
    Pharmacy.
    Pharmacology.
    Endocrinology.
    Biomedicine.
    Pharmacology/Toxicology.
    Endocrinology.
    Pharmacy.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9783642645198
  • ISBN
    9783642607097
  • 언어
    영어