소장자료

The Cancer Degradome Proteases and Cancer Biology [electronic resource] :

  • Edwards, Dylan. editor. , H첩yer-Hansen, Gunilla. editor. , Blasi, Francesco. editor. , Sloane, Bonnie F. editor.
  • 2008
The Cancer Degradome Proteases and Cancer Biology [electronic resource] :
  • 자료유형
    단행본
  • 서명/저자사항
    The Cancer Degradome[electronic resource] :Proteases and Cancer Biology / edited by Dylan Edwards, Gunilla H첩yer-Hansen, Francesco Blasi, Bonnie F. Sloane.
  • 개인저자
    Edwards, Dylan., editor., H첩yer-Hansen, Gunilla., editor., Blasi, Francesco., editor., Sloane, Bonnie F., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    XXIV, 926 p. 90 illus., 33 illus. in color. With 2 16-page inserts. : online resource.
  • 내용주기
    The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP?? A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor?밐ost Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor?밄one Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials ??The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors.
  • 일반주제명
    Medicine.
    Cancer research.
    Human genetics.
    Immunology.
    Medical microbiology.
    Molecular biology.
    Virology.
    Biomedicine.
    Cancer Research.
    Human Genetics.
    Medical Microbiology.
    Immunology.
    Virology.
    Molecular Medicine.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9780387690568
  • ISBN
    9780387690575
  • 언어
    영어