소장자료

Antibody-Drug Conjugates [electronic resource]

  • Ducry, Laurent. editor.
  • 2013
Antibody-Drug Conjugates [electronic resource]
  • 자료유형
    단행본
  • 서명/저자사항
    Antibody-Drug Conjugates[electronic resource] / edited by Laurent Ducry.
  • 개인저자
    Ducry, Laurent., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    X, 317 p. 96 illus., 42 illus. in color. : online resource.
  • 총서명
    Methods in Molecular Biology, Methods and Protocols,1064-3745 ; 1045
  • 내용주기
    Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review -- Antibody-Drug Conjugate Target Selection: Critical Factors -- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization -- Antibody-Drug Conjugate Payloads -- Linker Technologies for Antibody-Drug Conjugates -- In Vivo Testing of Drug-Linker Stability -- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates -- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment -- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting -- Protocols for Lysine Conjugation -- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers -- Enzymatic Antibody Modification by Bacterial Transglutaminase -- Formulation Development of Antibody-Drug Conjugates -- Conjugation Process Development and Scale-Up -- Methods for Conjugating Antibodies to Nanocarriers -- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS -- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF -- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs).
  • 일반주제명
    Medicine.
    Pharmacology.
    Oncology.
    Biomedicine.
    Pharmacology/Toxicology.
    Oncology.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9781627035408
  • ISBN
    9781627035415
  • 언어
    영어