소장자료

Quinolone Antibacterials [electronic resource]

  • Kuhlmann, J. editor. , Dalhoff, A. editor. , Zeiler, H.-J. editor.
  • 1998
Quinolone Antibacterials [electronic resource]
  • 자료유형
    단행본
  • 서명/저자사항
    Quinolone Antibacterials[electronic resource] / edited by J. Kuhlmann, A. Dalhoff, H.-J. Zeiler.
  • 개인저자
    Kuhlmann, J., editor., Dalhoff, A., editor., Zeiler, H.-J., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    XVIII, 491 p. : online resource.
  • 총서명
    Handbook of Experimental Pharmacology,0171-2004 ; 127
  • 내용주기
    1 History and Introduction -- A. Chemistry -- B. Antibacterial Activity -- C. Oxygen and 4-Quinolones -- D. 4-Quinolone Kinetics and Distribution in Humans -- E. Outlook -- References -- 2 The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System -- A. Introduction -- B. Methods of Synthesizing the Quinolone Ring System -- References -- 3 The Chemistry of the Quinolones: Chemistry in the Periphery of the Quinolones -- A. Introduction -- B. 1-Position -- C. 2-Position -- D. 3-Position -- E. 4-Position -- F. 5-Position -- G. 6-Position -- H. 7-Position -- I. 8-Position -- References -- 4 Mode of Action -- A. Introduction -- B. Effects on Bacteria -- C. Effects on DNA Gyrase -- D. Mode of Binding -- E. Mechanism of Cell Killing -- F. Conclusions and Future Prospects -- References -- 5 The In Vitro Antibacterial Activity of Quinolones: A Review -- A. Introduction -- B. In Vitro Activity -- C. The Future -- References -- 6 Pharmacokinetics of Fluoroquinolones in Experimental Animals -- A. Introduction -- B. Norfloxacin -- C. Pefloxacin -- D. Enoxacin -- E. Ofloxacin -- F. Ciprofloxacin -- G. Temafloxacin -- H. Tosufloxacin -- I. Fleroxacin -- J. Lomefloxacin -- K. Sparfloxacin -- L. Penetration of Quinolones at Sites of Infection -- References -- 7 Pharmacodynamics of Fluoroquinolones in Experimental Animals -- A. Introduction -- B. Bacterial Killing In Vivo -- C. In Vivo Postantibiotic Effects -- D. Pharmacodynamic Parameters Determining Efficacy -- E. Emergence of Resistance to Fluoroquinolones -- References -- 8 Interaction of Quinolones with Host-Parasite Relationship -- A. Introduction -- B. Effect on Adherence -- C. Effect Against Slowly Growing Bacteria -- D. Effect on Exoenzyme Production -- E. Quinolone-Induced Endotoxin Release -- F. Summary -- References -- 9 Mechanisms of Resistance to Fluoroquinolones -- A. Introduction -- B. Target Site Modification -- C. Reduced Intracellular Accumulation -- D. Reduced Killing -- E. Prevalence of Fluoroquinolone Resistance -- F. Distribution of Resistance Mechanisms -- G. Summary -- References -- 10 Toxicology and Safety Pharmacology of Quinolones -- A. Introduction -- B. Arthropathy -- C. Achilles Tendinitis and Rupture -- D. Nephropathy -- E. Effects on Central Nervous System -- F. Ocular Toxicity -- G. Impairment of Spermatogenesis -- H. Cardiovascular Effects -- I. Possible Mutagenic and Carcinogenic Effects -- J. Phototoxicity -- K. Photocarcinogenicity and Photomutagenicity -- L. Drug Interactions -- M. Metabolic and Nutritional Effects -- N. Conclusion -- References -- 11 Clinical Pharmacology -- A. Introduction -- B. Pharmacokinetics of Fluoroquinolone Antibiotics -- C. Interactions of Fluoroquinolone Antibiotics with Other Drugs -- D. Adverse Reactions of Fluoroquinolones -- References -- 12 Concentration-Effect Relationship of the Fluoroquinolones -- A. Introduction -- B. Pharmacodynamic Data of Antimicrobials as a Basis for Clinical Use -- C. Pharmacokinetic Aspects -- D. Summary and Conclusion -- References -- 13 Clinical Use of Quinolones -- A. Introduction -- B. Urinary Tract Infections and Prostatitis -- C. Gastrointestinal Infections and Traveller?셲 Diarrhea -- D. Respiratory Tract Infections -- E. Osteomyelitis -- F. Skin and Skin Structure Infection -- G. Sexually Transmitted Diseases -- H. Intra-abdominal Infections -- I. Bacteremia and Sepsis -- J. Surgical Prophylaxis -- K. Infections in Neutropenic Patients -- L. Use of Quinolones in Pediatrics -- M. Remarks -- References -- 14 Future Aspects -- A. Introduction -- B. Molecular Structure and Mechanism of Action -- C. Antimicrobial Activity -- D. Bacterial Resistance -- E. Future Use of Quinolones in Pediatrics -- F. Antitumor Potential -- G. New Attitudes -- H. Directions of Future Research on the Quinolones -- References.
  • 일반주제명
    Medicine.
    Pharmacology.
    Internal medicine.
    Biochemistry.
    Microbiology.
    Biomedicine.
    Pharmacology/Toxicology.
    Biochemistry, general.
    Microbiology.
    Internal Medicine.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9783642803666
  • ISBN
    9783642803642
  • 언어
    영어