소장자료

Antifolate Drugs in Cancer Therapy [electronic resource]

  • Jackman, Ann L. editor.
  • 1999
Antifolate Drugs in Cancer Therapy [electronic resource]
  • 자료유형
    단행본
  • 서명/저자사항
    Antifolate Drugs in Cancer Therapy[electronic resource] / edited by Ann L. Jackman.
  • 개인저자
    Jackman, Ann L., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    X, 456 p. : online resource.
  • 총서명
    Cancer Drug Discovery and Development
  • 내용주기
    1 Antifolate Drugs: Past and Future Perspectives -- 2 Folate Biochemistry in Relation to Antifolate Selectivity -- 3 Clinical Pharmacology and Resistance to Dihydrofolate Reductase Inhibitors -- 4 Development of Nonpolyglutamatable DHFR Inhibitors -- 5 Fluoropyrimidines as Antifolate Drugs -- 6 Raltitrexed (Tomudextm), a Highly Polyglutamatable Antifolate Thymidylate Synthase Inhibitor: Design and Preclinical Activity -- 7 Tomudex: Clinical Development -- 8 Preclinical Pharmacology Studies and the Clinical Development of a Novel Multitargeted Antifolate, MTA (LY231514) -- 9 GW1843: A Potent, Noncompetitive Thymidylate Synthase Inhibitor?봒reclinical and Preliminary Clinical Studies -- 10 Preclinical and Clinical Studies with the Novel Thymidylate Synthase Inhibitor Nolatrexed Dihydrochloride (Thymitaqtm, AG337) -- 11 ZD9331: Preclinical and Clinical Studies -- 12 Preclinical and Clinical Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitors Lometrexol and LY309887 -- 13 AG2034: A GARFT Inhibitor with Selective Cytotoxicity to Cells that Lack a G1 Checkpoint -- 14 Receptor- and Carrier-Mediated Transport Systems for Folates and Antifolates: Exploitation for Folate-Based Chemotherapy and Immunotherapy -- 15 Folates as Chemotherapeutic Modulators -- 16 Antifolate Polyglutamylation in Preclinical and Clinical Antifolate Resistance -- 17 Antifolates in Combination Therapy -- 18 Pharmacodynamic Measurements and Predictors of Response to Thymidylate Synthase Inhibitors -- 19 Molecular Regulation of Expression of Thymidylate Synthase -- 20 The Role of Uracil Misincorporation in Thymineless Death -- 21 Thymineless Death -- 22 Genetic Determinants of Cell Death and Toxicity.
  • 일반주제명
    Pharmacy.
    Pharmacy.
    Pharmacy.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9781475745214
  • ISBN
    9781592597253
  • 언어
    영어