소장자료

Optimization in Drug Discovery In Vitro Methods [electronic resource] :

  • Yan, Zhengyin. editor. , Caldwell, Gary W. editor.
  • 2004
Optimization in Drug Discovery In Vitro Methods [electronic resource] :
  • 자료유형
    단행본
  • 서명/저자사항
    Optimization in Drug Discovery[electronic resource] :In Vitro Methods / edited by Zhengyin Yan, Gary W. Caldwell.
  • 개인저자
    Yan, Zhengyin., editor., Caldwell, Gary W., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    XVI, 420 p. : online resource.
  • 총서명
    Methods in Pharmacology and Toxicology,1557-2153
  • 내용주기
    pKa, Solubility, and Lipophilicity -- Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism -- Absorption Screening Using the PAMPA Approach -- In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism -- In Vitro Permeation Study With Bovine Brain Microvessel Endothelial Cells -- An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors -- Evaluation of Drug-Transporter Interactions Using In Vitro Cell Models -- Plasma Protein-Binding Methods in Drug Discovery -- Isothermal Titration Calorimetry Characterization of Drug-Binding Energetics to Blood Proteins -- Metabolic Stability Assessed by Liver Microsomes and Hepatocytes -- In Vitro Drug Metabolite Profiling Using Hepatic S9 and Human Liver Microsomes -- In Vitro Identification of UDP-Glucuronosyltransferases (UGTs) Involved in Drug Metabolism -- In Vitro CYP Induction in Human Hepatocytes -- High-Throughput Screening of Human Cytochrome P450 Inhibitors Using Fluorometric Substrates -- Evaluation of Cytochrome P450 Inhibition in Human Liver Microsomes -- Identification of CYP Mechanism-Based Inhibitors -- Detection of DNA Adducts by 32P-Postlabeling Analysis -- Covalent DNA Adduct Formation Mediated by Cytochrome P450 -- Application of In Vitro Comet Assay for Genotoxicity Testing -- Assessing DNA Damage Using a Reporter Gene System -- Improvement of the Ames Test Using Human Liver S9 Preparation -- Screening for Chemical Mutagens Using the Mouse Lymphoma Assay -- A High-Throughput Binding Assay for HERG -- In Vitro Drug Metabolism -- In Vitro Screening Assay of the Reactivity of Acyl Glucuronides.
  • 일반주제명
    Pharmacy.
    Pharmacy.
    Pharmacy.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9781588293329
  • ISBN
    9781592598007
  • 언어
    영어