소장자료

Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson?셲 Disease [electronic resource]

  • Triarhou, Lazaros C. author.
  • 2002
Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson?셲 Disease [electronic resource]
  • 자료유형
    단행본
  • 서명/저자사항
    Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson?셲 Disease[electronic resource] / by Lazaros C. Triarhou.
  • 개인저자
    Triarhou, Lazaros C., author.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    X, 148 p. : online resource.
  • 총서명
    Advances in Experimental Medicine and Biology,0065-2598 ; 517
  • 내용주기
    1. Introduction -- Dopamine and Parkinson?셲 Disease -- Experimental Models of Parkinsonism in Laboratory Animals -- Graft-Assisted Neural Reconstruction (?쏝rainware Engineering??) -- References -- 2. Biology And Pathology of the Weaver Mutant Mouse -- Cellular and Molecular Genetics of the Weaver Mutation -- Alterations of the Mesotelencephalic Dopamine Projection System -- Cerebellar Phenotype of the Weaver Mutant -- Hippocampal Morphology -- Biology of Normal ? Mutant Cell Associations -- Behavioral Phenotype -- Structural Clues to the Weaver Riddle -- References -- 3. Histochemical Properties of Intrastriatal Mesencephalic Grafts -- Methodological Considerations -- Expression of Catecholaminergic Neurotransmitter-Related Molecules and Quantitative Aspects of Dopaminergic Neuron Survival -- Comparative Survival of Dopaminergic Neurons in Grafts Placed in Weaver and in 6-OHDA Lesion Hosts -- Expression of Neuropeptides and Structural Proteins -- References -- 4. Structural Correlates of Process Outgrowth and Circuit Reconstruction -- Axonal Reinnervation of the Host Striatum -- Synaptic Investment of Graft-Derived Dopamine Terminals -- Compartmental Specificity of the Striatal Reinnervation -- Innervation of Nonstriatal Regions by the Grafts -- Chemoaffinity and Axon-Target Recognition in Development and in Transplantation -- Dendrite Extension from the Graft into the Host Striatum -- Expression of Molecules Related to Axonal and Dendritic Outgrowth -- References -- 5. Neurochemical Indices of Functional Restoration -- Dopamine Uptake Markers -- Autoradiography of [3H]Dopamine Uptake -- Dopamine Receptors -- Neurotensin Receptors -- Excitatory and Inhibitory Amino Acid Receptors -- References -- 6. Behavioral Recovery of Functional Responses -- Unilateral Grafts and Circling Behavior -- Correlation of Turning Bias with Structural and Biochemical Parameters -- Dissociation of the Functional Contribution of Graft-Derived Axons and Dendrites in Rotational Asymmetry -- Enhancement of Motor Performance after Bilateral Transplantation -- References -- 7. Directions for Future Research -- Analysis of Early Events in Graft-Host Interactions -- Trophic Considerations -- Neurotransmitter Mechanisms -- Supplemental Restoration of the Interrupted Nigro-Striato-Nigral Loop by Striatal/Nigral Double Grafts -- References.
  • 일반주제명
    Medicine.
    Neurosciences.
    Public health.
    Surgical transplantation.
    Biomedicine.
    Neurosciences.
    Transplant Surgery.
    Public Health.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9781461352013
  • ISBN
    9781461506997
  • 언어
    영어