- Side Effects of Anti-Inflammatory Drugs IV[electronic resource] :The Proceedings of the IVth International Meeting on Side Effects of Anti-inflammatory Drugs, held in Sheffield, UK, 7?? August 1995 / edited by K. D. Rainsford.
- Rainsford, K. D., editor.
- SpringerLink (Online service)
- XII, 356 p. : online resource.
- I. Introduction -- Current status of side-effects from anti-inflammatory drugs -- II. Clinico-Epidemiological Aspects -- The placebo response: clinical efficacy and toxicity -- Side-effects of non-steroidal anti-inflammatory drugs: studies from the Tayside Medicines Monitoring Unit -- Treatment decisions, side-effect liability and cost-effectiveness in osteoarthritis -- Measuring beneficial and adverse events in osteoarthritis clinical trials -- Do NSAIDs adversely affect joint pathology in osteoarthritis? -- Safety of non-steroidal anti-inflammatory drugs during pregnancy and lactation -- Side-effects from biologics in the therapy of rheumatic diseases -- Oral tolerance from a general perspective, and the possible role of side-effects in the gut -- Summary of Debate: Management of side-effects from anti-inflammatory drugs -- III. Fundamental Aspects -- The concept of conditional pharmacology and toxicology -- Inflammation, stress and environmental factors as determinants of NSAID efficacy and toxicity -- Do you really know what your drug looks like or how it reacts? -- IV. Gastrointestinal Tract ??Clinical Aspects -- Intestinal pathology from NSAIDs -- A clinician?셲 view of strategies for preventing NSAID-induced gastrointestinal ulcers -- Protection from NSAID-induced gastrointestinal damage -- An overview of the key role of misoprostol in the prophylaxis of NSAIDassociated ulcers and their complications -- Clinical update of the relative safety of nabumetone in long-term clinical trials -- Global analysis of gastrointestinal safety of a new NSAID, meloxicam -- V. Gastrointestinal Tract ??Experimental -- Gastrointestinal adaptation, eicosanoids, and mucosal protection from NSAIDs -- New insight into NSAID-induced gastropathy -- Cyclooxygenase selectivity and NSAIDs: cyclooxygenase-2 selectivity of etodolac (Lodine) -- Differential inhibition of cyclooxygenase-1 (COX-1) and -2 (COX-2) by NSAIDs: Consequences on anti-inflammatory activity versus gastric and renal safety -- Polymer delivery of the mucosal protective prostaglandin misoprostol -- Nitric oxide-releasing NSAIDs, a novel class of safe and effective anti-inflammatory agents -- Mitochondrial function and modification of NSAID carboxyl moiety -- Effects of a new class of NO-releasing NSAIDs on platelets and isolated arteries -- A1 and A2 adenosine receptors mediate opposite effects on NSAID-induced gastric ulcers in the rat -- Role of vagal nerve in defence mechanisms against NSAIDs-induced gastrointestinal mucosal damage -- Analysis of the inhibiting activity of presynaptic a2-adrenoceptors against NSAID-induced gastric mucosal lesions in the rat -- VI. Dermatoxicity -- Mechanisms of adverse reactions in the skin from anti-rheumatic drugs -- Can in-vitro assays predict chemically-induced skin damage? -- VII. Novel Therapies -- The use of ketorolac tromethamine oral rinse for the treatment of periodontitis in adults -- VIII. Abstracts -- Variability in risk of major upper gastro-intestinal complications with individual NSAIDs. Importance of drug dose and half-life; results of meta analysis -- Non-steroidal associated ulcer bleeding ??defining the risk factors -- Variability in exposure to NSAIDs in relation to safety -- Non-steroidal anti-inflammatory drugs and infertility -- Perioperative use of NSAID and postoperative infectious complications -- Medico-legal issues of non-steroidal anti-inflammatory drugs (NSAIDs) -- The use of DMARDs and combination therapies -- Non-steroidal anti-inflammatory drugs and acute appendicitis: a case-control study -- Non-steroidal anti-inflammatory drugs and colitis: a record-linkage case-control study -- New exposure to NSAIDs and hospitalisation for upper gastrointestinal events -- Topical NSAIDs and upper gastrointestinal bleeding and perforation -- Non-steroidal anti-inflammatory drugs, aspirin and colo-rectal cancer -- The pattern of prescribing of community dispensed ulcer-healing drugs in Tayside -- Clinical trials of the relative safety of nabumetone in long-term clinical trials: proposed rationale for safety profile -- Cyclooxygenase-2: a novel target for safety anti-inflammatory drugs -- Inhibitory action of hydrophilic polymers on gastric lesions induced by indomethacin in rats -- Copper-derivatives and gastroprotection -- The ?3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat -- IX. Epilogue -- The dilemma of modern medicine.
Medicine & Public Health.
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- Printed edition: 9789401062695