소장자료

The Pharmacology of Pain [electronic resource]

  • Dickenson, A. editor. , Besson, J.-M. editor.
  • 1997
The Pharmacology of Pain [electronic resource]
  • 자료유형
    단행본
  • 서명/저자사항
    The Pharmacology of Pain[electronic resource] / edited by A. Dickenson, J.-M. Besson.
  • 대등서명
    With contributions by numerous experts
  • 개인저자
    Dickenson, A., editor., Besson, J.-M., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    XXII, 479 p. : online resource.
  • 총서명
    Handbook of Experimental Pharmacology,0171-2004 ; 130
  • 내용주기
    1 Animal Models of Analgesia -- A. Introduction -- B. Animal Models and Ethics -- C. Factors Affecting Measurements of Nociception -- D. Tests of Nociception and Analgesia -- E. Comparative Aspects -- F. Conclusion -- References -- 2 Peripheral Mediators of Pain -- A. Introduction -- B. Chemical Signalling in Fine Afferent Neurones -- C. Mediators Generated by Tissue Damage and Inflammation -- D. Mediators Released from Neurones -- E. Inflammatory Mediators from Immune Cells -- F. Exogenous Modulators of Sensory Fibre Activity: Vanilloids (Capsaicin Analogues) -- G. Ion Channels Activity and Chronic Pain -- H. Summary -- References -- 3 Non-steroidal Anti-inflammatory Drugs and Pain -- A. Inflammatory Pain and NSAIDs -- B. Cyclo-oxygenase -- C. Prostaglandins and Inflammatory Pain -- D. Nitric Oxide and Nociception -- E. Conclusion -- References -- 4 The Sympathetic Nervous System and Pain -- A. Introduction -- B. The Emergence of the Concept of an Interaction Between the Sympathetic and the Somatosensory System -- C. Sympathetic Activation Has a Negligible Effect on Normal Sensory Processing -- D. Several Interactions Between the Sympathetic and the Nociceptive Systems Develop After Nerve Injury -- E. Can the Sympathetic Nervous System Modulate Pain and Hyperalgesia Under Inflammatory Conditions? -- References -- 5 Excitability Blockers: Anticonvulsants and Low Concentration Local Anesthetics in the Treatment of Chronic Pain -- A. Introduction -- B. Anticonvulsants in the Treatment of Neuropathic Pain -- C. Systemically Administered Local Anesthetics in the Treatment of Neuropathic Pain -- D. Mechanisms of Action: Anticonvulsants and Local Anesthetics Suppress Abnormal Primary Afferent Firing -- E. Summary -- References -- 6 Tachykinins: Central and Peripheral Effects -- A. Introduction -- B. Substance P and NK-1 Receptors -- C. NK-1 Receptor Antagonists -- D. Therapeutic Potential of Drugs Acting at NK-1 Receptors -- E. Summary -- References -- 7 Growth Factors and Pain -- A. Introduction -- B. NGF and Its Receptors -- C. NGF as A Mediator of Persistent Pain -- D. Mechanisms of NGF-Induced Hyperalgesia -- E. Growth Factors and Neuropathic Pain -- F. Conclusions -- References -- 8 Mechanisms of Central Hypersensitivity: Excitatory Amino Acid Mechanisms and Their Control -- A. Central Hypersensitivity -- B. Substrates for Central Hypersensitivity -- C. Mechanisms of Central Hypersensitivity -- D. NMDA Antagonists and Spinal Hypersensitivity in Persistent Pain States -- E. Controlling NMDA Receptor Activation -- F. Indirect Influences on NMDA Receptor Activation -- G. Conclusions -- References -- 9 Novel Modulators in Nociception -- A. Introduction -- B. Nitric Oxide -- C. Cholecystokinin -- D. Galanin -- References -- 10 Pharmacological Studies of Nociceptive Systems Using the C-Fos Immunohistochemical Technique: An Indicator of Noxiously Activated Spinal Neurones -- A. Introduction -- B. Spinal Expression of c-Fos: Physiological Aspects -- C. Pharmacological Aspects -- D. Conclusion -- References -- 11 Molecular Aspect of Opioid Receptors -- A. Introduction -- B. cDNA Cloning of Opioid Receptors -- C. cDNA Cloning of an Opioid-like Orphan Receptor -- D. Structural Features of the Opioid Receptor Family -- E. Opioid Receptor Genes -- F. Conclusion: Reconciling Pharmacology and Gene Cloning? -- References -- 12 Opioid Pharmacology of Acute and Chronic Pain -- A. Introduction -- B. Pharmacological Characterization -- C. Physiological Roles -- D. Pathological Roles: Opioids and Neuropathic Pain -- E. Conclusions -- References -- 13 Opioid Problems, and Morphine Metabolism and Excretion -- A. Clinical Aspects -- B. Morphine and Metabolites -- C. Conclusions -- References -- 14 Inhibitory Neurotransmitters and Nociception: Role of GABA and Glycine -- A. Introduction -- B. GABA -- C. Glycine -- D. Summary -- References -- 15 The Role of Descending Noradrenergic and Serotoninergic Pathways in the Modulation of Nociception: Focus on Receptor Multiplicity -- A. General Introduction -- B. Control of Sympathetic and Motor Function at the Segmental Level: Relevance to Pain and Its Modulation -- C. Noradrenaline, Adrenaline and Adrenergic Receptors -- D. Serotonin and Serotonin Receptors -- E. General Discussion and Conclusions -- References -- 16 Neonatal Pharmacology of Pain -- A. Introduction -- B. Neonatal Pharmacology of Excitatory Pathways Involved in Pain -- C. Neonatal Pharmacology of Inhibitory Pathways Involved in Pain -- D. Concluding Comments -- References.
  • 일반주제명
    Medicine.
    Human physiology.
    Immunology.
    Pharmacology.
    Anesthesiology.
    Pain medicine.
    Biomedicine.
    Pharmacology/Toxicology.
    Human Physiology.
    Pain Medicine.
    Anesthesiology.
    Immunology.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9783642645501
  • ISBN
    9783642607776
  • 언어
    영어