소장자료

Rational Design of Stable Protein Formulations Theory and Practice [electronic resource] :

  • Carpenter, John F. editor. , Manning, Mark C. editor.
  • 2002
Rational Design of Stable Protein Formulations Theory and Practice [electronic resource] :
  • 자료유형
    단행본
  • 서명/저자사항
    Rational Design of Stable Protein Formulations[electronic resource] :Theory and Practice / edited by John F. Carpenter, Mark C. Manning.
  • 개인저자
    Carpenter, John F., editor., Manning, Mark C., editor.
  • 단체저자
    SpringerLink (Online service)
  • 형태사항
    XVII, 206 p. : online resource.
  • 총서명
    Pharmaceutical Biotechnology,1078-0467 ; 13
  • 내용주기
    1 Practical Approaches to Protein Formulation Development -- Preparation for Formulation Development -- Preformulation Development -- Formulation Development -- Formulation in Commercial Product Development -- Appendix: List of Regulatory Documents -- References -- 2 Recombinant Production of Native Proteins from Escherichia coli -- Distribution of Expressed Proteins -- Cell Washing and Lysis -- Purification of Soluble, Folded Proteins -- Purification and Refolding of Soluble, Misfolded Proteins -- Purification and Refolding of Proteins from Inclusion Bodies -- Refolding Mechanism -- Methods to Analyze Folded Structures -- References -- 3 Physical Stabilization of Proteins in Aqueous Solution -- Overview of Physical Stability -- Interactions of Excipients with Proteins -- Physical Factors Affecting Protein Stability -- Conclusions -- Appendix: Derivation of the Wyman Linkage Function and Application to the Timasheff Preferential Exclusion Mechanism -- References -- 4 Effects of Conformation on the Chemical Stability of Pharmaceutically Relevant Polypeptides -- Relationship Between Structure and Deamidation Rates -- Role of Structure in Protein Oxidation -- Summary -- References -- 5 Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice -- Minimal Criteria for a Successful Lyophilized Formulation -- Rational Design of Stable Lyophiilized Formulations -- Acknowledgments -- References -- 6 Spray-Drying of Proteins -- Introduction: Why Spray-Dry a Protein? -- Developments in the Last 10 Years -- The Practice of Spray-Drying Proteins -- Concluding Remarks -- References -- Chapter7 Surfactant-Protein Interactions -- Proteins and Surfactants at Surfaces -- Protein-Surfactant Interactions in Solution -- Surfactant Effects on Protein Assembly State -- Surfactant Effects on Proteins During Freezing, Freeze-Drying and Reconstitution -- Enzymatic Degradation of Non-Ionic Surfactants -- Recommendations for Protein Formulation -- References -- 8 High Throughput Formulation: Strategies for Rapid Development of Stahle Protein Products -- Overall Structure of the HTF Approach -- Role of an Established Decision Tree for Formulation Design -- Use of Software and Databases to Assist in the HTF Process -- Essential Analytical Methods -- Stability Protocols -- Unified Strategy for HTF -- References.
  • 일반주제명
    Medicine.
    Pharmacy.
    Pharmacology.
    Biotechnology.
    Biochemistry.
    Biomedicine.
    Pharmacology/Toxicology.
    Pharmacy.
    Biochemistry, general.
    Biotechnology.
  • 기본자료 저록
    Springer eBooks
  • 기타형태 저록
    Printed edition: 9781461351313
  • ISBN
    9781461505570
  • 언어
    영어