Molecular Biology of Aging [electronic resource]

  • Reddy, P.Hemachandra
  • Academic Press
  • 2017
Molecular Biology of Aging [electronic resource]


Chapter One: Clinical Aspects of Glucose Metabolism and Chronic Disease

1 Introduction
2 Diabetes Mellitus
3 Cardiovascular Disease
4 Chronic Kidney Disease
5 Sarcopenia
6 The Frailty Syndrome
7 Dementia
8 Exercise and Brain Metabolism
9 Pharmacological Treatments for Dementia
10 Reducing Chronic Disease Burden
Chapter Two: Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders

1 Introduction
2 Global Prevalence of Metabolic Disorders
3 Structure and Functions of Mitochondria
4 Mitochondrial Dysfunction in Age-Related Metabolic Disorders
5 Strategies Directed to Target Mitochondrial Dysfunction
6 Concluding Remarks
Chapter Three: MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases

1 Introduction
2 Circulatory miRNAs
3 miRNAs Secretion in Circulatory Biofluids
4 Circulatory miRNAs as Biomarkers in Aging and Age-Associated Diseases
5 Concluding Remarks
Chapter Four: Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer's Disease

1 Introduction
2 Risk Factors for IS, VaD, and AD
3 Molecular Links and Pathways
4 Molecular Biomarkers
5 Concluding Remarks
Chapter Five: MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease

1 Introduction
2 Biogenesis and Regulation of miRNAs
3 miRNA, Aging, and Cellular Senescence
4 miRNAs, Cellular Senescence, and Pathways
5 miRNAs and Neurodegenerative Diseases
6 Concluding Remarks
Chapter Six: Mitochondria-Targeted Molecules as Potential Drugs to Treat Patients With Alzheimer's Disease

1 Introduction
2 Aβ and Alzheimer's Disease
3 Phosphorylated Tau and Alzheimer's Disease
4 Synaptic Damage and Alzheimer's Disease
5 Decreased Glucose Metabolism and Alzheimer's Disease
6 Mitochondria and ROS in Aging and Alzheimer's Disease
7 Aβ and Phosphorylated Tau in Mitochondria
8 Natural Antioxidants and Mitochondrial Therapeutic Approaches to Alzheimer's Disease
9 Human Clinical Trials and Perspective Studies on Alzheimer's Disease
10 Therapies for Alzheimer's Disease Using Mitochondria-Targeted Molecules
11 Evidence Supporting Neuronal Function in MCAT Mice
12 Conclusions and Future Studies
Chapter Seven: Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models

1 Introduction
2 Life Span and Healthspan Extension in Mice-Overexpressing Catalase
3 The Contribution of mCAT Mouse Models to the Study of Diseases
4 Pleotropic or Adverse Effects of mCAT Expression
5 Pharmacologic Analogs of mCAT Expression
Chapter Eight: Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease

1 Alzheimer's Disease Is a Convergent Syndrome With Mixed Pathologies
2 Cellular Phase of AD
3 Cross Talk Between MetS and the Cellular Phase of AD
4 Targeting SIRT3 to Improve Metabolic Adaptation During the Cellular Phase of AD
5 Microglial Priming During MetS
6 Peripheral and Central Inflammation Connection
7 Overlap of VaD With AD
8 Neurovascular Unit Facilitates MetS–AD Cross Talk
9 Cerebral Ischemia and AD
Chapter Nine: Mitochondria, Cybrids, Aging, and Alzheimer's Disease

1 Introduction
2 Mitochondria and Aging
3 Mitochondria and Alzheimer's Disease
4 AD Cytoplasmic Hybrid (Cybrid) Studies
5 Conclusions
Chapter Ten: The Kidney in Aging: Physiological Changes and Pathological Implications

1 Introduction
2 Evaluation of Renal Function
3 Calcium, Phosphorus, and Magnesium Disorders in Aging
4 Conclusions
Chapter Eleven: Mitochondrial Perturbation in Alzheimer's Disease and Diabetes

1 Introduction
2 Mitochondrial Function
3 Synaptic Mitochondrial Pathology in AD
4 Impact of CypD-Dependent mPTP on Mitochondrial Defects
5 Effect of Neuronal PreP Activity and RAGE Signaling on Mitochondrial Dysfunction
6 Effects of Methionine Sulfoxide Reductase on Aβ Solubility and Mitochondrial Function
7 Impact of Mitochondrial Dynamics in MCI and AD
8 Drp1-Mediated Mitochondrial Abnormalities in Diabetes
9 Conclusion