Computational biology of Non-Coding RNA: methods and protocols [electronic resource]

  • Lai, Xin , Gupta, Shailendra K. , Vera, Julio
  • Springer
  • 2019
Computational biology of Non-Coding RNA: methods and protocols [electronic resource]
  • Data Type
  • Title/Author
    Computational biology of Non-Coding RNA:methods and protocols[electronic resource] / edited by Xin Lai, Shailendra K. Gupta, Julio Vera.
  • Publication
    New York, NY : Springer, 2019.
  • Author
    Lai, Xin, Gupta, Shailendra K., Vera, Julio
  • Phy Desc.
    1 online resource.
  • Total State.
    Methods in Molecular Biology1064-3745 ; 1912
  • Topical Term
    Human genetics
  • ISBN
    9781493989812, 9781493989829
  • Language


This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Table of Content

NcRNAs in Inflammatory and Infectious Diseases
p73-Governed miRNA Networks: Translating Bioinformatics Approaches to Therapeutic Solutions for Cancer Metastasis
Methods for Annotation and Validation of Circular RNAs from RNAseq Data
Methods to Study Long Non-coding RNA Expression and Dynamics in Zebrafish using RNA Sequencing
Workflow Development for the Functional Characterization of ncRNAs
ncRNA Editing: Functional Characterization and Computational Resources
Computational Prediction of Functional microRNA
mRNA Interactions
Tools for Understanding miRNA-mRNA Interactions for Reproducible RNA Analysis
Computational Resources for Prediction and Analysis of Functional miRNA and their Targetome
Non-coding RNAs Databases: Current Status and Trends
Controllability Methods for Identifying Associations between Critical Control ncRNAs and Human Diseases
Network-based Methods and Other Approaches for Predicting lncRNA Functions and Disease Associations
Integration of miRNA and mRNA Expression Data for Understanding Etiology of Gynecologic Cancers
Quantitative Characteristic of ncRNA Regulation in Gene Regulatory Networks
Kinetic Modeling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs
Modeling ncRNA-mediated Circuits in Cell Fate Decision
Modeling Long ncRNA-mediated Regulation in the Mammalian Cell Cycle.