Catalog

Blood Cell Biochemistry Hematopoiesis and Gene Therapy [electronic resource] :

  • Fairbairn, Leslie J. editor. , Testa, Nydia G. editor.
  • 1999
Blood Cell Biochemistry Hematopoiesis and Gene Therapy [electronic resource] :
  • Data Type
    Book
  • Title/Author
    Blood Cell Biochemistry[electronic resource] :Hematopoiesis and Gene Therapy / edited by Leslie J. Fairbairn, Nydia G. Testa.
  • Author
    Fairbairn, Leslie J., editor., Testa, Nydia G., editor.
  • Authors
    SpringerLink (Online service)
  • Phy Desc.
    XVI, 380 p. : online resource.
  • Total State.
    Blood Cell Biochemistry,1078-0491 ; 8
  • Contents Note
    1 Hemopoietic Stem Cells as Targets for Genetic Manipulation: Concepts and Practical Approaches -- 1. How Many Stem Cells Do We Need? -- 2. Selection and Identification by Phenotype and Function -- 3. Sources of Primitive Hematopoietic Cells -- 4. How Can We Maximize the Number of Target Cells? -- 5. Concluding Comments -- 6. References -- 2 Bone Marrow Transplantation for Genetic Diseases -- 1. Introduction -- 2. General Principles of BMT -- 3. The Bone Marrow Transplantation Process -- 4. Complications of BMT -- 5. Results of BMT -- 6. Future Directions -- 7. References -- 3 Retroviral Vectors -- 1. Why Retroviruses? -- 2. The Basic Vector -- 3. The Packaging Cell -- 4. References -- 4 Parvoviral Vectors for Human Hematopoietic Gene Therapy -- 1. Introduction -- 2. Life Cycle of Human Parvoviruses -- 3. Recombinant Parvoviral Vectors -- 4. Parvovirus-Mediated Transduction and Expression of Genes -- 5. Advantages and Disadvantages of Parvovirus Vectors -- 6. Summary and Conclusions -- 7. Future Prospects -- 8. References -- 5 Nonviral Methods for Gene Transfer -- 1. Introduction -- 2. Plasmid DNA-Based Methods -- 3. Artificial Self-Assembling Systems -- 4. References -- 6 Prospects for Gene Therapy of Inherited Immunodeficiency -- 1. Introduction to Gene Therapy -- 2. Immunodeficiency Disorders -- 3. Vector Systems and Their Suitability for Gene Therapy of Immunodeficiency -- 4. Gene Therapy for Immunodeficiency Disorders -- 5. Conclusion -- 6. References -- 7 Gene Therapy for Lysosomal Disorders -- 1. Defining a Population of Patients Suitable for Treatment -- 2. Gene Therapy -- 3. Targeting the Brain -- 4. Conclusions -- 5. References -- 8 Genetic Approaches to Therapy for the Hemoglobinopathies -- 1. Introduction -- 2. Current Therapies for ?-Thalassaemia -- 3. Current Therapies for Sickle Cell Disease -- 4. Regulation of Gene Expression from the Human ?-Globin Locus -- 5. Pharmaceutical Activation of Fetal ?-Globin Gene Expression in the Adult -- 6. Gene Therapy -- 7. Summary and Future Prospects -- 8. References -- 9 Gene Marking and the Biology of Hematopoietic Cell Transfer in Human Clinical Trials -- 1. Introduction -- 2. Gene Marking and Cancer Biology -- 3. Retroviral Marking of Tumor-Infiltrating Lymphocytes -- 4. Clinical Trials of Stem Cell Gene Marking -- 5. Clinical Trial Design -- 6. Retroviral Marking of Malignant Cells -- 7. Clinical Trial Results -- 8. Hematopoiesis and Gene Marking -- 9. Genetically Marked Relapse -- 10. Retroviral Gene Marking and Purging Efficacy -- 11. Implications of Gene Marking Results in Clinical Practice -- 12. In Vitro Strategies to Improve Hematopoietic Stem Cell Targeting -- 13. Future Directions -- 14. Summary -- 15. References -- 10 Antisense Strategies to Leukemia -- 1. Introduction -- 2. Antisense and Ribozymal Design and Mechanisms of Action -- 3. Controls, Experimental Systems, and Difficulties in Interpretation -- 4. Antisense and Ribozymes in Experimental Hematology -- 5. Clinical Trials in Hematology -- 6. Future Prospects -- 7. References -- 11 Transfer of Drug Resistance Genes into Bone Marrow Stem and Progenitor Cells: Implications for Cancer Chemotherapy -- 1. Introduction -- 2. Current Strategies for Hematopoietic Support during Chemotherapy -- 3. Gene Transfer, Expression, and Stem Cell Protection -- 4. Further Considerations -- 5. Concluding Remarks -- 6. References -- 12 HIV Gene Therapy Using Hairpin Ribozymes in Hematopoietic Stem/Progenitor Cells -- 1. Ribozyme for Gene Therapy of AIDS -- 2. Gene Therapy Using Hematopoietic Stem/Progenitor Cells -- 3. Transduction of Stem/Progenitor Cells Using Ribozymal Constructs -- 4. Toward Clinical Trials -- 5. References -- 13 Molecular Immunotherapy by Gene Transfer -- 1. Introduction -- 2. Are Tumors Antigenic? -- 3. Antigen Presentation Pathways -- 4. Immunotherapy by Gene Transfer -- 5. Aims, Goals, and Targets for Gene Transfer in Immunotherapy -- 6. Unification of Diverse Results from Gene Transfer Studies -- 7. References -- 14 DNA-Based Immunization -- 1. Introduction -- 2. DNA Vaccines for Protection against Infectious Diseases -- 3. DNA Vaccines for Immunotherapy -- 4. Mechanism of Induction of Immune Responses -- 5. Safety Considerations -- 6. Summary and Future Directions -- 7. Implications for Gene Therapy -- 8. References.
  • Topical Term
    Medicine.
    Human genetics.
    Internal medicine.
    Hematology.
    Oncology.
    Medicine & Public Health.
    Internal Medicine.
    Oncology.
    Hematology.
    Human Genetics.
  • Host Item
    Springer eBooks
  • Additional Item
    Printed edition: 9781461372189
  • ISBN
    9781461548898
  • Language
    English