Manual of Antisense Methodology [electronic resource]

  • Hartmann, Gunther. editor. , Endres, Stefan. editor.
  • 1999
Manual of Antisense Methodology [electronic resource]
  • Data Type
  • Title/Author
    Manual of Antisense Methodology[electronic resource] / edited by Gunther Hartmann, Stefan Endres.
  • Author
    Hartmann, Gunther., editor., Endres, Stefan., editor.
  • Authors
    SpringerLink (Online service)
  • Phy Desc.
    XIII, 205 p. : online resource.
  • Total State.
    Perspectives in Antisense Science,1566-0389 ; 4
  • Contents Note
    I: The chemistry of antisense oligonucleotides -- 1. Chemical synthesis and purification of phosphorothioate antisense oligonucleotides -- 2. How to choose optimal antisense targets in an mRNA -- II: Antisense application in vitro -- 3. How to characterize and improve oligonucleotide uptake into leukocytes -- 4. Strategies for targeted uptake of antisense oligonucleotides in hepatocytes -- 5. How to exclude immunostimmulatory and other nonantisense effects of antisense oligonucleotides -- 6. Testing antisense oligonucleotides in controlled cell culture assays -- 7. Inhibition of TNF synthesis by antisense oligonucleotides -- 8. Inhibition of IGF-1 receptor expression by antisense oligonucleotides in vitro and in vivo -- III: Antisense application in vivo -- 9. How to test antisense oligonucleotides in animals -- 10. Lipid-based carriers for the systemic delivery of antisense drugs -- 11. Designing a clinical antisense study.
  • Topical Term
    Life sciences.
    Human genetics.
    Life Sciences.
    Biochemistry, general.
    Human Genetics.
  • Host Item
    Springer eBooks
  • Additional Item
    Printed edition: 9781461373049
  • ISBN
  • Language