Fragment-Based Methods in Drug Discovery [electronic resource]

  • Klon, Anthony E. editor.
  • 2015
Fragment-Based Methods in Drug Discovery [electronic resource]
  • Data Type
  • Title/Author
    Fragment-Based Methods in Drug Discovery[electronic resource] / edited by Anthony E. Klon.
  • Author
    Klon, Anthony E., editor.
  • Authors
    SpringerLink (Online service)
  • Phy Desc.
    IX, 230 p. 68 illus., 53 illus. in color. : online resource.
  • Total State.
    Methods in Molecular Biology,1064-3745 ; 1289
  • Contents Note
    Solvation Methods for Protein-Ligand Docking -- Binding Site Druggability Assessment in Fragment-Based Drug Design -- Generating "Fragment-Based Virtual Library" Using Pocket Similarity Search of Ligand-Receptor Complexes -- Virtual Fragment Preparation for Computational Fragment-Based Drug Design -- Fragment Library Design: Using Cheminformatics and Expert Chemists to Fill Gaps in Existing Fragment Libraries -- Protocol for Fragment Hopping -- Site Identification by Ligand Competitive Saturation (SILCS) Simulations for Fragment-Based Drug Design -- A Computational Fragment-Based De Novo Design Protocol Guided by Ligand Efficiency Indices (LEI) -- Scoring Functions for Fragment-Based Drug Discovery -- Computational Methods for Fragment-Based Ligand Design: Growing and Linking -- Design Strategies for Computational Fragment-Based Drug Design -- Protein Binding Site Analysis for Drug Discovery Using a Computational Fragment-Based Method -- Fragment-Based Design of Kinase Inhibitors: A Practical Guide -- Designing a Small Molecule Erythropoietin Mimetic -- Designing an Orally Available Non-Toxic p38 Inhibitor with a Fragment-Based Strategy.
  • Topical Term
  • Host Item
    Springer eBooks
  • Additional Item
    Printed edition: 9781493924851
  • ISBN
  • Language