E-Book

Neurotrophins [electronic resource]

  • Litwack, Gerald
  • Academic Press
  • 2017
Neurotrophins [electronic resource]
  • Data Type
    Book
  • Title/Author
    Neurotrophins[electronic resource] / Gerald Litwack.
  • Publication
    [Cambridge, MA] : Academic Press, 2017.
  • Author
    Litwack, Gerald
  • Phy Desc.
    1 online resource.
  • Total State.
    Vitamins and Hormones ; 104
  • ISSN
    0083-6729
  • ISBN
    9780128122631
  • Language
    English

Table of Content

Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain

Abstract
1 Introduction
2 Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain
3 Pharmacological Approach: The Selectivity Issue
4 Conclusion and Future Directions
Acknowledgments
Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity

Abstract
1 Neurotrophins and Their Biological Actions
2 NT Receptors and Their Signaling
3 Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein
4 Modulation of Synaptic Function by BDNF
5 BDNF Prodomain: New Roles Beyond a Molecular Chaperone
6 BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles
7 The BDNF Propeptide Is a Novel Synaptic Modulator
8 Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD
9 Discussion
Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments

Abstract
1 Introduction
2 Brain-Derived Neurotrophic Factor
3 Zinc in the Brain
4 Zinc(II) Interaction With BDNF and Related Peptides
5 Zinc, BDNF, and Diet
6 Conclusion
Acknowledgments
Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily

Abstract
1 TNFR Superfamily
2 Structural Characterization of p75NTR
3 The Transmembrane Domain (TMD)
4 The Intracellular Domain (ICD)
5 Conclusions and Future Directions
Acknowledgments
Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid

Abstract
1 Introduction
2 Biochemical Features of BDNF
3 Regions and Cellular Distribution of BDNF
4 Extracellular Secretion of BDNF
5 Conclusion
Acknowledgments
Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling

Abstract
1 Introduction
2 The Coronin Family of Proteins
3 Type I Coronins as Actin Regulators
4 Coronin-1a as a Signaling Effector Protein
5 Conclusions and Future Directions
Acknowledgments
Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors

Abstract
1 Introduction
2 The BICD Family of Cargo Adaptors
3 Role of BicD in Drosophila Development
4 Mammalian BICDs and Their Role in Mitotic Cells
5 Role of BICD in Neurons
6 BICDs and NT Signaling
7 Conclusions
Acknowledgments
Chapter Eight: BDNF and Hippocampal Synaptic Plasticity

Abstract
1 Introduction
2 Basic Mechanisms of LTP
3 The Neurotrophin Family and Its Receptors
4 TrkB Localization and Signaling
5 Synthesis and Secretion of BDNF
6 BDNF and LTP in the Hippocampus
7 p75NTR and LTD
8 Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress
9 Concluding Remarks
Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development

Abstract
1 Introduction
2 Neurotrophins and the Developing Brain
3 Alcohol as a Teratogenic Agent
4 Neurotrophins as Targets of Alcohol Exposure
5 Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects
6 Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects
7 Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure
8 Conclusions
Acknowledgments
Chapter Ten: Neurotrophins: Role in Placental Growth and Development

Abstract
1 Introduction
2 Role of Neurotrophins in Placental Growth and Development
3 Neurotrophins in Different Regions of the Placenta
4 Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development
5 Role of Neurotrophins in Pregnancy
6 Conclusion and Future Directions
Acknowledgments
Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases

Abstract
1 Introduction
2 Mammalian Neurotrophin Ligand–Receptor System
3 Neurotrophin Ligand–Receptor Biological Functionality
4 Proneurotrophin-Based Therapy for Age-Related Neurodegeneration
5 Future Developments in Small-Molecule Neurotrophic Agents
Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy

Abstract
1 Introduction
2 NTs and Allergic Disease
3 NTs and Inflammatory Responses
4 Conclusions
Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy

Abstract
1 Introduction
2 Neurotrophic Factors
3 Maternal Nutrition
4 Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle
5 Consequences of Altered Maternal Nutrition in Pregnancy
Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/CD271)

Abstract
1 General Overview
2 Malignant Glioma: A Major Clinical Challenge
3 Glioma Disease Reservoirs
4 Molecular Determinants of Glioma Invasion and Progression
5 The Role of the Neurotrophins and Their Cognate Receptors in Glioma Progression
6 A Role for p75NTR in Cancer: Extending Beyond Glioma
7 Conclusions and Future Directions
Acknowledgments
Chapter Fifteen: Neurotrophic Factors Used to Treat Spinal Cord Injury

Abstract
1 Introduction
2 Neurotrophins
3 Selected Examples of Other Growth Factors
4 Combinations of Factors
5 Location of Neurotrophic Factor Delivery
6 Mode of Neurotrophic Factor Delivery
7 Timing of Neurotrophic Factor Delivery
8 Conclusion
Acknowledgments
Chapter Sixteen: Neurotrophins and Migraine

Abstract
1 Introduction
2 Neurotrophins and Pain
3 Migraine Pathophysiology
4 Neurotrophins and Migraine
5 Conclusion and Future Directions
Chapter Seventeen: BDNF During Withdrawal

Abstract
1 Introduction
2 BDNF Alterations Following Chronic Administration of Drugs of Abuse
3 Protracted Abstinence, Incubation, and Craving: How Is BDNF Involved?
4 Peripheral BDNF Levels
5 Polymorphism in BDNF Gene: Predictive Value in Drug Addiction?
6 Conclusion and Future Directions
Acknowledgments
Chapter Eighteen: Neurotrophin Receptors and Perineural Invasion: Analyses in Select Lineage-Unrelated Cutaneous Malignancies With a Propensity for Perineural Invasion

Abstract
1 Introduction
2 PNI in Cancer
3 Definitions
4 Incidence of PNI in Cutaneous Malignancies
5 Prognostic Impact of PNI in cSCC and DM
6 The Biological Underpinnings of PNI: The Role of Neurotrophins
7 Clinical Potential of Neurotrophins as Therapeutic Targets
8 Personal Observations
9 Conclusions