A general introduction -- to schizophrenia -- From first to second generation antipsychotics -- Animal models for schizophrenia: an introduction -- The preclinical evaluation of atypical antipsychotics -- Receptor profile of antipsychotics -- Regional selectivity of antipsychotic drugs -- Screening models for antipsychotic drugs -- Simulation models for schizophrenia -- The clinical evaluation of atypical antipsychotics -- Clozapine: the first atypical antipsychotic -- Dopamine receptor subtypes and schizophrenia: a clinical perspective -- Multireceptor atypical antipsychotic drugs -- New discoveries in the development of antipsychotics with novel mechanisms of action: beyond the atypical antipsychotics with serotonin dopamine antagonism.