1. Diabetes in the United States: epidemiology, scope and impact -- 2. Stages of diabetic nephropathy -- 3. Mesangial expansion in diabetic nephropathy: functional and genetic considerations -- 4. Nephropathy in NIDDM ??an update -- 5. Clinical imperatives in diabetic nephropathy: the devastating impact of comorbidity -- 6. Dialysis in diabetic patients: three decades of experience, from 1964 to 1997 -- 7. Hemodialysis in patients with diabetes mellitus -- 8. Continuous ambulatory peritoneal dialysis in 224 diabetics with end stage renal disease: evidence of improved survival over the past 10 years -- 9. The natural history and classification of diabetic retinopathy -- 10. Long-term visual outcome of diabetic patients treated with panretinal photocoagulation -- 11. A new hypothesis on mechanisms of retinal vascular permeability in diabetes -- 12. Angiogenesis in diabetic retinopathy: a history of accomplishment, discovery and promise -- 13. Surgical management of proliferative diabetic retinopathy -- 14. Heart disease in patients with the diabetic renal-retinal syndrome: clinical considerations -- 15. NO and diabetic complications -- 16. AGE and the kidney: an update -- 17. Xenotransplantation of encapsulated porcine islets -- 18. Generation of non-immunogenic islet cells using genetic engineering -- 19. Insulin-independence for > 10 years in 32 pancreas transplant recipients from a historical era -- 20. Giving up: discontinuation of dialysis.